Zbyněk Prokop






Loschmidt Laboratories, Faculty of Science, Masaryk University, Kamenice 5/A4, 625 00 Brno, Czech Republic














enzyme kinetics, biocatalysis in organic synthesis, engineering of dehalogenating enzymes




Short CV:


1998 visiting scholar with Colin Janssen, University of Ghent, Belgium
since 2000 research specialist at National Centre for Biomolecular Research and Loschmidt Laboratories, Faculty of Science, Masaryk University, Brno, Czech Republic
2001 Ph.D. with Ivan Holoubek, Masaryk University, Czech Republic
2001-2004 visiting scholar with Dick Janssen, University of Groningen, The Netherlands






2000 1st place, Student Poster Competition, 5th International Symposium on Environmental Contamination in Central and Eastern Europe
2003 Young Microbiologist of the Year from the Czechoslovak Microbiological Society
2005 Excellence in Innovation Award from the Rector of Masaryk University
2005 Alfred Bader Prize for Bioorganic Chemistry from the Czech Chemical Society






Nagata, Y., Prokop, Z., Sato, Y., Jerabek, P., Kumar, A., Ohtsubo, Y., Tsuda, M., Damborsky, J. Degradation of γ-Hexachlorocyclohexane by Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26. Appl. Environ. Microbiol. 71: 2183-2185 (2005).
Prokop, Z., Monincová, M., Chaloupková, R., Klvaňa, M., Janssen, D.B., Nagata, Y., Damborský, J. Catalytic Mechanism of the Haloalkane Dehalogenase from Sphingomonas paucimobilis UT26. J. Biol. Chem. 278: 45094-45100 (2003).
Chaloupková, R., Sýkorová, J., Prokop, Z., Jesenská, A., Monincová, M., Pavlová, M., Nagata, Y., Damborský, J. Modification of Activity and Specificity of Haloalkane Dehalogenase from Sphingomonas paucimobilis UT26 by Engineering of its Entrance Tunnel. J. Biol. Chem. 278: 52622-52628 (2003).
Nagata, Y., Prokop, Z., Marvanova, S., Sykorova, J., Monincova, M., Tsuda, M., Damborsky, J. Re-construction and Characterization of Mycobacterial Dehalogenase Rv2579 by Cumulative Mutagenesis of Haloalkane Dehalogenase LinB. Appl. Environ. Microbiol. 69: 2349-2355 (2003).
Streltsov, V.A., Prokop, Z., Damborsky, J., Nagata, Y., Wilce, M.C.J. Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26: X-ray Crystallographic Studies of Dehalogenation of Brominated Substrates. Biochemistry 42: 10104-10112 (2003).






Prokop, Z., Damborský, J., Nagata, Y., Janssen, D. B. Method of Production of Optically Active Halohydrocarbons and Alcohols using Hydrolytic Dehalogenation Catalysed by Haloalkane Dehalogenases. CZ 2004-1240 A1 (2004).
Prokop, Z., Damborský, J., Opluštil, F., Jesenská, A., Nagata, Y. Method of Sulfur Mustard Detoxication by using Haloalkane Dehalogenases. CZ 2005-352 A1 (2005).