Name:

Dana Hocková

Affiliation:

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 16610 Prague 6, Czech Republic

E-mail:

lasice@uochb.cas.cz

Web:

http://www.uochb.cas.cz/~nk/

Research:

medicinal chemistry, modified nucleobases, "abbreviated" NAD analogues, synthesis of acyclic nucleoside and nucleotide analogues, structure-activity relationship

Short CV:

1993 MSc. Institute of Chemical Technology, Prague, Czech Republic
 
1993-1996 Ph.D. with Antonín Holý, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
 
1997 postdoc with Leon Ghosez at the Department of Chemistry, Université Catholique de Louvain, Louvain-la-Neuve, Belgium
 
since 1998 research scientist, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
 

Awards:

2004 Alfred Bader Prize for Organic Chemistry from the Czech Chemical Society
 

Publications:

Hocková D., Masojídková M., Holý A.: "Abbreviated" NAD+ analogues containing a phosphonate function. Collect. Czech. Chem. Commun. 61: 1538-1548 (1996).
 
Hocková D., Buděšínský M., Marek R., Marek J., Holý A.: Regioselective preparation of N-7- and N-9-alkyl derivatives of N-6-[(dimethylamino)methylene]adenine bearing an active methylene group and their further derivatization leading to alpha-branched acyclic nucleoside analogues. Eur. J. Org. Chem.: 2675-2682 (1999).
 
Hocková D., Holý A., Masojídková M., Andrei G., Snoeck R., De Clercq, E., Balzarini J.: 5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines - Acyclic Nucleoside Phosphonate Analogues with Antiviral Activity. J. Med. Chem. 46: 5064-5073 (2003).
 
Hocková D., Holý A., Masojídková M., Votruba I.: An efficient synthesis of cytostatic mono and bis-alkynylpyrimidine derivatives by the Sonogashira cross-coupling reactions of 2,4-diamino-6-iodopyrimidine and 2-amino-4,6-dichloropyrimidine. Tetrahedron 60: 4983-4987 (2004).
 
Hocková D., Holý A., Masojídková M., Andrei G., Snoeck R., De Clercq E., Balzarini J.: Synthesis and Antiviral Activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and Related Compounds. Bioorganic & Medicinal Chemistry 12: 3197-3202 (2004).
 

Research interest:

Design and synthesis of new acyclic nucleoside and nucleotide analogues targeted towards potentially cytostatic and antiviral compounds. This effort is focused on chemistry of purine and pyrimidine, application of new methods for the preparation of modified nucleobases and synthesis of acyclic nucleoside phosphonates (ANP) as the leading structural group of antiviral derivatives.