Name:

Michal Hocek

Affiliation:

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 16610 Prague 6, Czech Republic

E-mail:

hocek@uochb.cas.cz

Web:

http://www.uochb.cas.cz/~sbm/

Research:

modified nucleobases and nucleosides, organic synthesis, organometallic reagents, medicinal chemistry

Short CV:

1993-1996 Ph.D. with Antonín Holý, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
 
1997 postdoc with Leon Ghosez at the Department of Chemistry, Université Catholique de Louvain, Louvain-la-Neuve, Belgium
 
since 1998 staff scientist, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
 
since 2002 group leader, Group of Modified Nucleobases, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
 

Awards:

1999 Alfred Bader Prize for Organic Chemistry from the Czech Chemical Society
 

Editorships:

since 1998 Collection of Czechoslovak Chemical Communications, Editor-in-Chief
 

Publications:

Hocek, M.; Votruba, I.: "Covalent Analogues of DNA Base-Pairs and Triplets II. Synthesis and Cytostatic Activity of is(purin-6-yl)acetylenes, -diacetylenes and Related Compounds". Bioorg. Med. Chem. Lett. 12: 1055-1057 (2002).
 
Hocek, M., Štěpnička, P., Ludvík, J., Císařová, I., Votruba, I., Řeha, D., Hobza, P. Ferrocene-Modified Purines as Potential Electrochemical Markers: Synthesis, Crystal Structures, Electrochemistry and Cytostatic Activity of (Ferrocenylethynyl)- and (Ferrocenylethyl)purines. Chem. Eur. J. 10: 2058-2066 (2004).
 
Hocek, M., Dvořáková, H. An Efficient Synthesis of 2-Substituted 6-Methylpurine Bases and Nucleosides by Fe- or Pd-Catalyzed Cross-Coupling Reactions of 2,6-Dichloropurines. J. Org. Chem. 68: 5773-5776 (2003).
 
Hocek, M., Votruba, I., Dvořáková, H. Synthesis of Carba-Analogues of Myoseverine by Regioselective Cross-coupling Reactions of 2,6-Dichloro-9-isopropylpurine. Tetrahedron 59: 607-611 (2003).
 
Hocek, M.: "Syntheses of Purines Bearing Carbon Substituents in Positions 2, 6 or 8 by Metal- or Organometallics-Mediated C-C Bond Forming Reactions". Eur. J. Org. Chem.: 245-254 (2003).
 

Research interest:

Synthesis of novel modified nucleobases (in particular purines) and their derivatives (nucleosides) is the main goal of the group. Basic new synthetic methodologies (largely using modern transition metal-catalyzed reactions) are developed for the synthesis of novel types of analogues of nucleobases, nucleosides and base-pairs and are applied in the synthesis of new derivatives directed to medicinal chemistry (biological activity screening of new nucleobases and nucleosides), bioanalytical applications (sensors of nucleic acids hybridization) and chemical biology (design and synthesis of novel types of base-pairs and analogues).